The colorectal cancer tumor microenvironment and its impact on liver and lung metastasis

R Chandra, JD Karalis, C Liu, GZ Murimwa, J Voth Park… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the third most common cancer worldwide.
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …

The role of sinusoidal endothelial cells in the axis of inflammation and cancer within the liver

AL Wilkinson, M Qurashi, S Shetty - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

C Rolny, M Mazzone, S Tugues, D Laoui, I Johansson… - Cancer cell, 2011 - cell.com
Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-
suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of …

Prominent receptors of liver sinusoidal endothelial cells in liver homeostasis and disease

E Pandey, AS Nour, EN Harris - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …

Liver sinusoidal endothelial cells

KK Sørensen, J Simon‐Santamaria… - Comprehensive …, 2011 - Wiley Online Library
The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic
sinusoid and functions as a control post regulating and surveying the trafficking of molecules …

The scavenger endothelial cell: a new player in homeostasis and immunity

KK Sørensen, P McCourt, T Berg… - American Journal …, 2012 - journals.physiology.org
To maintain homeostasis, the animal body is equipped with a powerful system to remove
circulating waste. This review presents evidence that the scavenger endothelial cell (SEC) is …

Liver endothelial cells in NAFLD and transition to NASH and HCC

RI Velliou, AI Legaki, P Nikolakopoulou… - Cellular and Molecular …, 2023 - Springer
Non-alcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of
metabolic syndrome, which is characterised by obesity, insulin resistance …

[HTML][HTML] The role of liver sinusoidal endothelial cells in cancer liver metastasis

M Yang, C Zhang - American Journal of Cancer Research, 2021 - ncbi.nlm.nih.gov
Liver sinusoidal endothelial cells (LSECs) are the gatekeeper cells in the liver, contributing
critical roles in liver physiological and pathological changes. Factors such as dietary …

Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor‐associated macrophages

P Allavena, M Chieppa, G Bianchi… - Journal of …, 2010 - Wiley Online Library
Tumor‐Associated Macrophages (TAMs) are abundantly present in the stroma of solid
tumors and modulate several important biological processes, such as neoangiogenesis …

Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic …

Z Qiu, Y Wang, Z Zhang, R Qin, Y Peng, W Tang… - Frontiers in …, 2022 - frontiersin.org
Colorectal cancer (CRC) is a major global health problem and one of the major causes of
cancer-related death worldwide. It is very important to understand the pathogenesis of CRC …