Deciphering combinatorial post-translational modifications by top-down mass spectrometry

JS Brodbelt - Current opinion in chemical biology, 2022 - Elsevier
Post-translational modifications (PTMs) create vast structural and functional diversity of
proteins, ultimately modulating protein function and degradation, influencing cellular …

Constructing human proteoform families using intact-mass and top-down proteomics with a multi-protease global post-translational modification discovery database

Y Dai, KE Buxton, LV Schaffer, RM Miller… - Journal of proteome …, 2019 - ACS Publications
Complex human biomolecular processes are made possible by the diversity of human
proteoforms. Constructing proteoform families, groups of proteoforms derived from the same …

Two novel angiotensin‐converting enzyme (ACE) and dipeptidyl peptidase IV (DPP‐IV) inhibiting peptides from tilapia (Oreochromis mossambicus) skin and their …

J Chen, H Ji, J Luo, D Zhang, S Liu - Journal of Food Science, 2024 - Wiley Online Library
In the study, papain was used to hydrolyze tilapia (Oreochromis mossambicus) skin to obtain
a tilapia skin hydrolysate (TSH) with dual angiotensin‐converting enzyme (ACE) and …

Evaluation of bottom-up and top-down mass spectrum identifications with different customized protein sequences databases

Z Li, B He, W Feng - Bioinformatics, 2020 - academic.oup.com
Motivation Generally, bottom-up and top-down are two complementary approaches for
proteoforms identification. The inference of proteoforms relies on searching mass spectra …

Development of analytical and bioinformatics strategies in mass spectrometry for the characterization of therapeutic proteins and their impurities

C Beaumal - 2023 - theses.hal.science
Mass spectrometry has been a technique of choice for the characterization of proteins. This
Ph. D. work aims to develop analytical and bioinformatics strategies in mass spectrometry to …

The International Conference on Intelligent Biology and Medicine (ICIBM) 2018: bioinformatics towards translational applications

X Liu, L Xie, Z Wu, K Wang, Z Zhao, J Ruan, D Zhi - BMC bioinformatics, 2018 - Springer
Abstract The 2018 International Conference on Intelligent Biology and Medicine (ICIBM
2018) was held on June 10–12, 2018, in Los Angeles, California, USA. The conference …