Hypoxia and acidosis are salient features of many tumors, leading to a completely different
metabolism compared to normal cells. Two of the simplest metabolic products, protons and …

Variations in oxygen levels play key roles in numerous physiological and pathological
processes, but are often not properly controlled in in vitro models, introducing a significant …

The availability of ultra-high-affinity small organic ligands, which are specific to accessible
cancer antigens, is crucially important to enable efficient and selective tumor targeting …

Targeted radionuclide theranostics is becoming more and more prominent in clinical
oncology. Currently, most nuclear medicine compounds researched for cancer theranostics …

The use of radiolabelled antibodies was proposed in 1970s for staging of malignant
tumours. Intensive research established chemistry for radiolabelling of proteins and …

Theranostics is the integration of diagnostic information with pharmaceuticals to increase
effectiveness and safety of cancer treatments. Nuclear medicine provides a non-invasive …

Studies concerning the development of radiopharmaceuticals based on the Tc (I) carbonyl
core are considered from the coordination-chemical viewpoint. The coordination behavior of …

Human epidermal growth factor receptor 3 (HER3) is involved in the progression of various
cancers and in resistance to therapies targeting the HER family. In vivo imaging of HER3 …

Engineered scaffold proteins (ESP) are high-affinity binders that can be used as probes for
radionuclide imaging. Histidine-containing tags enable both efficient purification of ESP and …

Purpose Clear cell renal cell carcinoma (ccRCC) highly expresses carbonic anhydrase IX
(CAIX). The purpose of this study was to evaluate 68Ga-NY104, a small-molecule CAIX …