Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Biomedical applications of multinuclear Pt (II)/Ru (II)/Ir (III) metallo-supramolecular assemblies for intensive cancer therapy

X Li, X Zhao, W Wang, Z Shi, Y Zhang, Q Tian… - Coordination Chemistry …, 2023 - Elsevier
The development of highly efficient and minimally toxic agents with targeting abilities toward
tumor tissues is an ongoing area of research in the fight against cancer. Different from the …

Fine‐tuning of chiral microenvironments within triple‐stranded helicates for enhanced enantioselectivity

J Jiao, J Dong, Y Li, Y Cui - Angewandte Chemie, 2021 - Wiley Online Library
Here we report the formation of an unexpected and unique family of chiral helicates. Crystal
structures show that these triple‐stranded ZnII2L3 complexes are held together by …

Mitochondrial‐DNA‐Targeted IrIII‐Containing Metallohelices with Tunable Photodynamic Therapy Efficacy in Cancer Cells

X Li, J Wu, L Wang, C He, L Chen… - Angewandte Chemie …, 2020 - Wiley Online Library
The development of DNA‐targeted photodynamic therapy (PDT) agents for cancer treatment
has drawn substantial attention. Herein, the design and synthesis of dinuclear IrIII …

Approaches towards understanding the mechanism-of-action of metallodrugs

X Xiong, LY Liu, ZW Mao, T Zou - Coordination Chemistry Reviews, 2022 - Elsevier
Known as highly efficient metallodrugs that have been clinically used to treat various types
of cancers, cisplatin and its analogues have attracted and inspired extensive interest in the …

Maximized axial helicity in a Pd 2 L 4 cage: inverse guest size-dependent compression and mesocate isomerism

WM Bloch, S Horiuchi, JJ Holstein, C Drechsler… - Chemical …, 2023 - pubs.rsc.org
Helicity is an archetypal structural motif of many biological systems and provides a basis for
molecular recognition in DNA. Whilst artificial supramolecular hosts are often helical, the …

A triangular platinum (II) multinuclear complex with cytotoxicity towards breast cancer stem cells

A Eskandari, A Kundu, S Ghosh… - Angewandte …, 2019 - Wiley Online Library
The preparation of multinuclear metal complexes offers a route to novel anticancer agents
and delivery systems. The potency of a novel triangular multinuclear complex containing …

A chiral cyclometalated iridium Star of David [2] catenane

DP August, J Jaramillo-Garcia, DA Leigh… - Journal of the …, 2021 - ACS Publications
Although circular helicates can be assembled with a range of labile transition-metal centers,
solely “chiral-at-metal” examples (ie, systems without chiral ligands) and heterometallic (ie …

Metallohelices emulate the properties of short cationic α-helical peptides

H Song, M Postings, P Scott, NJ Rogers - Chemical Science, 2021 - pubs.rsc.org
Naturally occurring peptides in many living systems perform antimicrobial and anticancer
host defence roles, but their potential for clinical application is limited by low metabolic …

Rotaxanating metallo-supramolecular nano-cylinder helicates to switch DNA junction binding

CAJ Hooper, L Cardo, JS Craig, L Melidis… - Journal of the …, 2020 - ACS Publications
A class of rotaxane is created, not by encapsulating a conventional linear thread, but rather
by wrapping a large cucurbit [10] uril macrocycle about a three-dimensional, cylindrical …