Cellular and molecular pathobiology of heart failure with preserved ejection fraction

S Mishra, DA Kass - Nature Reviews Cardiology, 2021 - nature.com
Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Oxidative stress and antioxidants in hypertension–a current review

N Sinha, P Kumar Dabla - Current hypertension reviews, 2015 - ingentaconnect.com
Free radicals or reactive oxygen species (ROS) are generated by oxygen metabolism which
is balanced by the rate of oxidant formation and the rate of oxidant elimination. Oxidative …

[HTML][HTML] Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants

A Baradaran, H Nasri… - Journal of research in …, 2014 - ncbi.nlm.nih.gov
Hypertension is a major risk factor for myocardial infarction, heart failure, stroke, peripheral
arterial disease, and aortic aneurysm, and is a cause of chronic kidney disease …

The role of oxidative stress in the pathophysiology of hypertension

R Rodrigo, J González, F Paoletto - Hypertension Research, 2011 - nature.com
Hypertension is considered to be the most important risk factor in the development of
cardiovascular disease. An increasing body of evidence suggests that oxidative stress …

Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?

RM Touyz - Hypertension, 2004 - Am Heart Assoc
Metabolism of oxygen by cells generates potentially deleterious reactive oxygen species
(ROS). Under normal conditions the rate and magnitude of oxidant formation is balanced by …

[HTML][HTML] Essential hypertension and oxidative stress: New insights

J González, N Valls, R Brito… - World journal of …, 2014 - ncbi.nlm.nih.gov
Essential hypertension is a highly prevalent pathological condition that is considered as one
of the most relevant cardiovascular risk factors and is an important cause of morbidity and …

Oxidative stress as a mediator of cardiovascular disease

MM Elahi, YX Kong, BM Matata - Oxidative medicine and …, 2009 - Wiley Online Library
During physiological processes molecules undergo chemical changes involving reducing
and oxidizing reactions. A molecule with an unpaired electron can combine with a molecule …

The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: the great exploration

R Hutcheson, P Rocic - Journal of Diabetes Research, 2012 - Wiley Online Library
The metabolic syndrome affects 30% of the US population with increasing prevalence. In
this paper, we explore the relationship between the metabolic syndrome and the incidence …

Metabolic syndrome as a multifaceted risk factor for oxidative stress

S Spahis, JM Borys, E Levy - Antioxidants & redox signaling, 2017 - liebertpub.com
Abstract Significance: Metabolic syndrome (MetS) is associated with a greater risk of
diabetes and cardiovascular diseases. It is estimated that this multifactorial condition affects …

Mechanisms of disease: pathologic structural remodeling is more than adaptive hypertrophy in hypertensive heart disease

J Díez, A González, B López, R Querejeta - Nature clinical practice …, 2005 - nature.com
Abstract Changes in the composition of cardiac tissue develop in arterial hypertension and
lead to structural remodeling of the myocardium. Structural remodeling is the consequence …