Dietary restriction (DR) is the most robust environmental manipulation known to increase
active and healthy lifespan in many species. Despite differences in the protocols and the …

Saccharomyces cerevisiae has directly or indirectly contributed to the identification of
arguably more mammalian genes that affect aging than any other model organism. Aging in …

Ageing results from complex genetically and epigenetically programmed processes that are
elicited in part by noxious or stressful events that cause programmed cell death. Here, we …

Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great
volume of knowledge in the field has been accumulated. Here we attempted to organize the …

Obesity and overweight have increased at an alarming rate in the world during the last three
decades. Obesity is a crucial factor in the development of metabolic abnormalities, including …

The free radical theory of aging posits oxidative damage to macromolecules as a primary
determinant of lifespan. Recent studies challenge this theory by demonstrating that in some …

Genome instability is a fundamentally important component of aging in all eukaryotes. How
age-related genome instability occurs remains unclear. The free radical theory of aging …

Senescence is defined as a stable cell growth arrest. Oncogene-induced senescence (OIS)
occurs when an activated oncogene is expressed in a normal cell. OIS acts as a bona fide …

The two paradigms to study aging in Saccharomyces cerevisiae are the chronological life
span (CLS) and the replicative life span (RLS). The chronological life span is a measure of …

The study of the chronological life span of Saccharomyces cerevisiae, which measures the
survival of populations of non-dividing yeast, has resulted in the identification of homologous …