Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Much effort has been made to generate human skin organ in the laboratory. Yet, the current
models are limited due to the lack of many critical biological and structural features of the …

A key to enhance the low translatability of preclinical drug discovery are in vitro human three-
dimensional (3D) microphysiological systems (MPS). Here, we show a new method for …

Tissue engineered skeletal muscle allows investigation of the cellular and molecular
mechanisms that regulate skeletal muscle pathology. The fabricated model must resemble …

When embedded into a three-dimensional (3D) matrix, cancer stem cells (or cancer-initiating
cells) can grow into self-organizing organotypic structures called tumor organoids. During …

Successful clinical translation of organoid technology requires insights that extend beyond
biology and biochemistry, notably from the fields of mechanical and computational biology …

Human intestinal organoids (HIOs) derived from pluripotent stem cells or adult stem cell
biopsies represent a powerful platform to study human development, drug testing, and …

Self‐assembly of cells into functional bioarchitectures with microscale spatial topographies
are prevalent in nature. Despite the advances to recapitulate the native‐like …

The extracellular matrix (ECM) plays a critical role in regulating cell-matrix interactions
during tumor progression. These interactions are due in large part to the biophysical …

Increased extracellular matrix (ECM) density in the tumor microenvironment has been
shown to influence aspects of tumor progression such as proliferation and invasion …