Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases
Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal
evolution and impact of treatment are poorly understood. We analyzed whole-exome …
evolution and impact of treatment are poorly understood. We analyzed whole-exome …
Tumor heterogeneity and the potential role of liquid biopsy in bladder cancer
HM Huang, HX Li - Cancer Communications, 2021 - Wiley Online Library
Bladder cancer (BC) is a heterogeneous disease that characterized by genomic instability
and a high mutation rate. Heterogeneity in tumor may partially explain the diversity of …
and a high mutation rate. Heterogeneity in tumor may partially explain the diversity of …
[HTML][HTML] Inferring mutational timing and reconstructing tumour evolutionary histories
Cancer evolution can be considered within a Darwinian framework. Both micro and macro-
evolutionary theories can be applied to understand tumour progression and treatment …
evolutionary theories can be applied to understand tumour progression and treatment …
The ocean sampling day consortium
A Kopf, M Bicak, R Kottmann, J Schnetzer, I Kostadinov… - Gigascience, 2015 - Springer
Abstract Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …
BS-SNPer: SNP calling in bisulfite-seq data
S Gao, D Zou, L Mao, H Liu, P Song, Y Chen… - …, 2015 - academic.oup.com
Sodium bisulfite conversion followed by sequencing (BS-Seq, such as whole genome
bisulfite sequencing or reduced representation bisulfite sequencing) has become popular …
bisulfite sequencing or reduced representation bisulfite sequencing) has become popular …
PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3β/CTNNB1 signaling …
Y Lin, Z Yang, A Xu, P Dong, Y Huang, H Liu, F Li… - Scientific reports, 2015 - nature.com
Abstract The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been
identified as an important pathway in renal cell carcinoma (RCC). We have reported a …
identified as an important pathway in renal cell carcinoma (RCC). We have reported a …
miR-486-5p regulates the migration and invasion of colorectal cancer cells through targeting PIK3R1
Y Zhang, J Fu, Z Zhang, H Qin - Oncology Letters, 2018 - spandidos-publications.com
The aim of the present study was to investigate the function of microRNA (miR)-486-5p in
colorectal cancer (CRC). Tumor and adjacent normal mucosal tissue samples were …
colorectal cancer (CRC). Tumor and adjacent normal mucosal tissue samples were …
β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver …
A Bleckmann, LC Conradi, K Menck… - Clinical & experimental …, 2016 - Springer
Liver metastasis development in breast cancer patients is common and confers a poor
prognosis. So far, the prognostic significance of surgical resection and clinical relevance of …
prognosis. So far, the prognostic significance of surgical resection and clinical relevance of …
Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by …
MB Mogensen, M Rossing, O Østrup, PN Larsen… - BMC cancer, 2018 - Springer
Background Colorectal cancer (CRC) patients with metastatic disease can become cured if
neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often …
neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often …
MesKit: a tool kit for dissecting cancer evolution of multi-region tumor biopsies through somatic alterations
M Liu, J Chen, X Wang, C Wang, X Zhang, Y Xie… - …, 2021 - academic.oup.com
Background Multi-region sequencing (MRS) has been widely used to analyze intra-tumor
heterogeneity (ITH) and cancer evolution. However, comprehensive analysis of mutational …
heterogeneity (ITH) and cancer evolution. However, comprehensive analysis of mutational …