Background Coumarins, abundantly distributed in a plethora of biologically active
compounds, serve as a fundamental motif in numerous natural products, drugs, and …

Natural coumarins and isocoumarins show significant therapeutic potential against cancer in
preclinical studies by targeting multiple pathways and processes. These compounds …

The ability of natural metalloproteins to prevent inactivation of their metal cofactors by
biological metabolites, such as glutathione, is an area that has been largely ignored in the …

This study investigated the purification and characterization of a new immunomodulatory
GlcNAc-containing polysaccharide (MIPB70-1) from Morchella importuna with molecular …

Introduction: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition.
Maternal separation (MS) stress is an early-life stress factor associated with behaviors …

Tumor angiogenesis is one of the most important processes of cancer deterioration via
nurturing an immunosuppressive tumor environment (TME). Targeting tumor angiogenesis …

Chemotherapy is standard treatments for many malignancies. However, in most cases, this
method is not able to induce apoptosis and in many cases, with cancer recurrence, leads to …

The aim of this survey was to load Umbelliprenin (UMB) on nanostructured lipid carriers
(NLCs) coated with folic acid-bound chitosan and to investigate its anti-cancer effects in vitro …

Treating breast cancer, especially in the invasive state, is one of the challenges in treating
cancer. Invasion and metastasis are factors in the failure of breast cancer treatments. One of …

Lipoxygenases (LOXs) are enzymes which found in organisms that catalyze the
peroxidation of polyunsaturated fatty acids (Arachidonic acid, Linoleic acid). The key role of …