Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

Many aspects of cell homeostasis and integrity are maintained by the nucleotide-binding
oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 …

Microglia, the resident immune cells of the brain, are increasingly implicated in the
regulation of brain health and disease. Microglia perform multiple functions in the central …

Mounting evidence suggests a role for oxidative stress and accumulation of dysfunctional
organelle and misfolded proteins in PD. Autophagosomes mediate the clearance of these …

Fluoxetine is a classic antidepressant drug, and its immunomodulatory effects have recently
been reported in many disease models. In addition, it has strong antineuroinflammatory …

In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1× C3D2F1 cross,
the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12%(p= 0.003 …

Background Microglia are innate immune cells in the central nervous system that play a
crucial role in neuroprotection by releasing neurotrophic factors, removing pathogens …

Neurodegenerative diseases have been a weighty problem in elder people who might be
stricken with motor or/and cognition defects with lower life quality urging for effective …

Activated microglia are divided into pro-inflammatory and anti-inflammatory functional states.
In anti-inflammatory state, activated microglia contribute to phagocytosis, neural repair and …

There is a striking sex-related difference in the prevalence of many neurodegenerative
diseases, highlighting the need to consider whether treatments may exert sex-specific …