The metabolism of glucose and lipids is essential for energy production in the body, and
dysregulation of the metabolic pathways of these molecules is implicated in various acute …

Obesity and related metabolic syndromes have been recognized as important disease risks,
in which the role of adipokines cannot be ignored. Adiponectin (ADP) is one of the key …

Nuclear receptors are ligand-regulated transcription factors that regulate vast cellular
activities and serve as an important class of drug targets. Among them, peroxisome …

Protein acetylation modifications play a central and pivotal role in a myriad of biological
processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and …

The formation of atherosclerotic plaques is one of the main sources of cardiovascular
disease. In addition to known risk factors such as dyslipidemia, diabetes, obesity, and …

Aging and obesity are the two prominent driving forces of metabolic dysfunction, yet the
common underlying mechanisms remain elusive. PPARγ, a central metabolic regulator and …

Adipose tissue is composed of adipocytes, stromal vascular fraction, nerves, surrounding
immune cells, and the extracellular matrix. Under various physiological or pathological …

In the genesis and progression of cardiovascular and metabolic diseases (CVMDs), adipose
tissue plays a pivotal and dual role. Complement factor D (CFD, also known as adipsin) …

Liver can sense the nutrient status and send signals to other organs to regulate overall
metabolic homoeostasis. Herein, we demonstrate that ketone bodies act as signals released …

Background Menin is a scaffold protein encoded by the Men1 gene, which interacts with
various transcriptional proteins to activate or repress cellular processes and is a key …