Oligodendrocytes are the myelinating glia of the central nervous system. Myelination of
axons allows rapid saltatory conduction of nerve impulses and contributes to axonal …

Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark
contrast to the situation that follows loss of neurons or axonal damage, remyelination in the …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

Multiple sclerosis is a common cause of neurological disability in young adults. The disease
is complex—its aetiology is multifactorial and largely unknown; its pathology is …

Laminins are heterotrimeric extracellular matrix proteins that regulate cell viability and
function. Laminin-2, composed of α2, β1, and γ1 chains, is a major matrix component of the …

Remyelination following central nervous system demyelination is essential to prevent axon
degeneration. However, remyelination ultimately fails in demyelinating diseases such as …

Although both extrinsic and intrinsic factors have been identified that orchestrate the
differentiation and maturation of oligodendrocytes, less is known about the intracellular …

Differentiation of oligodendrocyte progenitor cells requires activation of the Src family kinase
Fyn. The signals that are upstream and downstream of Fyn in oligodendrocytes remain …

Demyelinating disorders of the central nervous system are among the most crippling
neurological diseases affecting patients at various stages of life. In the most prominent …