Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …

Sexual dimorphisms account for differences in clinical manifestations or incidence of
infectious or autoimmune diseases and malignancy between females and males. Females …

PURPOSE Women have more adverse events (AEs) from chemotherapy than men, but few
studies have investigated sex differences in immune or targeted therapies. We examined …

Sex bias exists in the development and progression of nonreproductive organ cancers, but
the underlying mechanisms are enigmatic. Studies so far have focused largely on sexual …

INTRODUCTION Many complex human phenotypes, including diseases, exhibit sex-
differentiated characteristics. These sex differences have been variously attributed to …

Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …

A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Sex differences in the incidence and outcome of human disease are broadly recognized but,
in most cases, not sufficiently understood to enable sex-specific approaches to treatment …

Immune checkpoint blockade therapies have extended patient survival across multiple
cancer lineages, but there is a heated debate on whether cancer immunotherapy efficacy is …

The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer
development has increasingly been appreciated. Here, we present the detection and …