Designs of antigen structure and composition for improved protein-based vaccine efficacy
Today, vaccinologists have come to understand that the hallmark of any protective immune
response is the antigen. However, it is not the whole antigen that dictates the immune …
response is the antigen. However, it is not the whole antigen that dictates the immune …
In silico studies to support vaccine development
The progress that has been made in computer science positioned in silico studies as an
important and well-recognized methodology in the drug discovery and development …
important and well-recognized methodology in the drug discovery and development …
An integrated biophysical model for predicting the clinical pharmacokinetics of transdermally delivered compounds
The delivery of therapeutic drugs through the skin is a promising alternative to oral or
parenteral delivery routes because dermal drug delivery systems (D 3 Ss) offer unique …
parenteral delivery routes because dermal drug delivery systems (D 3 Ss) offer unique …
Engineering of a hybrid nanoparticle-based nicotine nanovaccine as a next-generation immunotherapeutic strategy against nicotine addiction: A focus on hapten …
Although vaccination is a promising way to combat nicotine addiction, most traditional
hapten-protein conjugate nicotine vaccines only show limited efficacy due to their poor …
hapten-protein conjugate nicotine vaccines only show limited efficacy due to their poor …
Attenuating nicotine's effects with high affinity human anti-nicotine monoclonal antibodies
MD Raleigh, N Beltraminelli, S Fallot, MG LeSage… - PLoS …, 2021 - journals.plos.org
Use of nicotine-specific monoclonal antibodies (mAbs) to sequester and reduce nicotine
distribution to brain has been proposed as a therapeutic approach to treat nicotine addiction …
distribution to brain has been proposed as a therapeutic approach to treat nicotine addiction …
Physiologically based pharmacokinetic modelling for nicotine and cotinine clearance in pregnant women
Introduction: Physiologically based pharmacokinetic (PBPK) models for the absorption,
disposition, metabolism and excretion (ADME) of nicotine and its major metabolite cotinine …
disposition, metabolism and excretion (ADME) of nicotine and its major metabolite cotinine …
Alum as an adjuvant for nanoparticle based vaccines: A case study with a hybrid nanoparticle-based nicotine vaccine
The treatment efficacy of a nicotine vaccine largely relies on its ability to induce high titers of
nicotine-specific antibodies. Due to its strong immune-potentiating effects, aluminum salt …
nicotine-specific antibodies. Due to its strong immune-potentiating effects, aluminum salt …
Toll-like receptor 9 agonists as adjuvants for nanoparticle-based nicotine vaccine
Nicotine vaccine was considered a promising therapy against smoking addiction. The level
of immune response that a nicotine vaccine can induce is pivotal to its efficacy. In this study …
of immune response that a nicotine vaccine can induce is pivotal to its efficacy. In this study …
Multi-epitope insert modulates solubility-based and chromatographic purification of human papilloma virus 16 L1-based vaccine without inhibiting virus-like particle …
The separation of heterogeneous protein mixtures has always been characterized by a trade-
off between purity and yield. One way this issue has been addressed in the past is by …
off between purity and yield. One way this issue has been addressed in the past is by …
Computational mining of MHC class II epitopes for the development of universal immunogenic proteins
The human leukocyte antigen (HLA) gene complex, one of the most diverse gene
complexes found in the human genome, largely dictates how our immune systems …
complexes found in the human genome, largely dictates how our immune systems …