DGKs (diacylglycerol kinases) are members of a unique and conserved family of
intracellular lipid kinases that phosphorylate DAG (diacylglycerol), catalysing its conversion …

C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes,
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …

Diacylglycerol (DAG) is an important lipid that is both an intermediate in lipid biosynthetic
pathways and can act as a signaling lipid. The majority of signaling DAG is generated by …

Recycling of internalized receptors from endosomal compartments is essential for the
receptors' cell-surface homeostasis. Sorting nexin 27 (SNX27) cooperates with the retromer …

Multivesicular bodies (MVBs) are endocytic compartments that contain intraluminal vesicles
formed by inward budding from the limiting membrane of endosomes. In T lymphocytes …

The mammalian diacylglycerol kinases (DGK) are a group of enzymes having important
roles in regulating many biological processes. Both the product and the substrate of these …

The protein known as mammalian target of rapamycin (mTOR) regulates cell growth by
integrating different stimuli, such as available nutrients and mitogenic factors. The lipid …

Seven-transmembrane receptor (7TMR) signaling is transduced by second messengers
such as diacylglycerol (DAG) generated in response to the heterotrimeric guanine …

The diacylglycerol kinases (DGK) are lipid kinases that transform diacylglycerol (DAG) into
phosphatidic acid (PA) in a reaction that terminates DAG-based signals. DGK provide …

Diacylglycerol kinase (DGK) plays an important role in signal transduction through
modulating the balance between two signaling lipids, diacylglycerol and phosphatidic acid …