Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack
U Ghani - European journal of medicinal chemistry, 2015 - Elsevier
Abstract Treatment of diabetes mellitus by oral α-glucosidase inhibitors is currently confined
to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects …
to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects …
Benzofuran-selenadiazole hybrids as novel α-glucosidase and cyclooxygenase-2 inhibitors with antioxidant and cytotoxic properties
TO Olomola, MJ Mphahlele, S Gildenhuys - Bioorganic chemistry, 2020 - Elsevier
Abstract Series of 2-arylbenzofuran–1, 2, 3-selenodiazole hybrids were prepared via
multiple reactions and then evaluated in vitro through enzymatic assay for inhibitory effect …
multiple reactions and then evaluated in vitro through enzymatic assay for inhibitory effect …
Inhibition effect of rhodanines containing benzene moieties on pentose phosphate pathway enzymes and molecular docking
Recently, inhibition studies of pentose phosphate pathway (PPP) enzymes have come out
as an encouraging approach for pharmacological intervention in a variety of disorders. For …
as an encouraging approach for pharmacological intervention in a variety of disorders. For …
Synthesis and α-glucosidase inhibitory activity of chrysin, diosmetin, apigenin, and luteolin derivatives
N Cheng, WB Yi, QQ Wang, SM Peng, XQ Zou - Chinese Chemical Letters, 2014 - Elsevier
Several derivatives have been synthesized from chrysin, diosmetin, apigenin, and luteolin,
which were isolated from diverse natural plants. The α-glucosidase inhibitory activity of …
which were isolated from diverse natural plants. The α-glucosidase inhibitory activity of …
Mitigation of starch-induced postprandial glycemic spikes in rats by antioxidants-rich extract of Cicer arietinum Linn. seeds and sprouts
AK Tiwari, C Sahana, A Zehra… - Journal of Pharmacy …, 2013 - journals.lww.com
Objectives: The study evaluated free radicals scavenging, antioxidant properties and
intestinal α-glucosidase inhibitory activity in methanol extract of two varieties of Cicer …
intestinal α-glucosidase inhibitory activity in methanol extract of two varieties of Cicer …
Synthesis and mosquito larvicidal activity of furanochalcones and furanoflavonoids analogous to karanjin
SR Satyavani, S Kanjilal, MS Rao, RBN Prasad… - Medicinal Chemistry …, 2015 - Springer
A series of furanoflavonoids analogous to karanjin have been synthesized starting from
resacetophenone. Initially, resacetophenone was reacted with bromoacetaldehyde …
resacetophenone. Initially, resacetophenone was reacted with bromoacetaldehyde …
Synthesis and structure–activity relationship studies of furan-ring fused chalcones as antiproliferative agents
Y Saito, M Kishimoto, Y Yoshizawa… - Anticancer …, 2015 - ar.iiarjournals.org
As part of our continuing investigation of flavonoid derivatives as potential anticancer
substances, the synthesis of 25 cinnamoyl derivatives of benzofuran as furan-fused …
substances, the synthesis of 25 cinnamoyl derivatives of benzofuran as furan-fused …
Chemopreventive flavonoids from Millettia pulchra Kurz var-laxior (Dunn) Z. Wei (Yulangsan) function as Michael reaction acceptors
Abstract Natural NQO1 [NAD (P) H quinine oxidoreductase 1] inducing agents play a critical
role in cancer chemoprevention. The expression of NQO1 is regulated by Michael reaction …
role in cancer chemoprevention. The expression of NQO1 is regulated by Michael reaction …
Synthesis of novel β-amino ketones containing a p-aminobenzoic acid moiety and evaluation of their antidiabetic activities
GX Tang, JF Yan, L Fan, J Xu, XL Song, L Jiang… - Science China …, 2013 - Springer
The synthesis of two series of β-amino ketones containing ap-aminobenzoic acid moiety (TM-
1 and TM-2) using a modified protocol of the Mannich reaction is reported. The molecular …
1 and TM-2) using a modified protocol of the Mannich reaction is reported. The molecular …
A fuzzy system classification approach for QSAR modeling of α-amylase and α-Glucosidase Inhibitors
K Diéguez-Santana, A Puris… - … -Aided Drug Design, 2022 - ingentaconnect.com
Introduction: This report proposes the application of a new Machine Learning algorithm
called Fuzzy Unordered Rules Induction Algorithm (FURIA)-C in the classification of druglike …
called Fuzzy Unordered Rules Induction Algorithm (FURIA)-C in the classification of druglike …