Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and …

PJ Rogers, PS Hogenkamp, C de Graaf… - International Journal of …, 2016 - nature.com
By reducing energy density, low-energy sweeteners (LES) might be expected to reduce
energy intake (EI) and body weight (BW). To assess the totality of the evidence testing the …

Revisiting the safety of aspartame

AK Choudhary, E Pretorius - Nutrition reviews, 2017 - academic.oup.com
Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods,
medications, and beverages, notably carbonated and powdered soft drinks. Since 1981 …

Transgenerational transmission of aspartame-induced anxiety and changes in glutamate-GABA signaling and gene expression in the amygdala

SK Jones, DM McCarthy, C Vied… - Proceedings of the …, 2022 - National Acad Sciences
We report the effects of aspartame on anxiety-like behavior, neurotransmitter signaling and
gene expression in the amygdala, a brain region associated with the regulation of anxiety …

[HTML][HTML] The protective effect of thymoquinone or/and thymol against monosodium glutamate-induced attention-deficit/hyperactivity disorder (ADHD)-like behavior in …

K Abu-Elfotuh, SA Abdel-Sattar, AN Abbas… - Biomedicine & …, 2022 - Elsevier
Both thymoquinone (TQ) and thymol (T) have been proved to possess a positive impact on
human health. In this research, we aimed to investigate the effect of these compounds …

[HTML][HTML] Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame

SJ Borghoff, SS Cohen, X Jiang, IA Lea… - Food and Chemical …, 2023 - Elsevier
Aspartame has been studied extensively and evaluated for its safety in foods and beverages
yet concerns for its potential carcinogenicity have persisted, driven primarily by animal …

Daily early-life exposures to diet soda and aspartame are associated with autism in males: A case-control study

SP Fowler, D Gimeno Ruiz de Porras, MD Swartz… - Nutrients, 2023 - mdpi.com
Since its introduction, aspartame—the leading sweetener in US diet sodas (DS)—has been
reported to cause neurological problems in some users. In prospective studies, the offspring …

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer's disease-like animal model

SS Ankul, L Chandran, S Anuragh… - Frontiers in …, 2023 - frontiersin.org
This systematic review analyzes monosodium glutamate (MSG) in the Alzheimer's disease-
like condition to enhance translational research. Our review seeks to understand how MSG …

Ameliorative Effect of Graviola (Annona muricata) on Mono Sodium Glutamate-Induced Hepatic Injury in Rats: Antioxidant, Apoptotic, Anti-inflammatory, Lipogenesis …

M Shukry, AM El-Shehawi, WM El-Kholy, RA Elsisy… - Animals, 2020 - mdpi.com
Simple Summary Food additives, especially monosodium glutamate (MSG), induces serious
liver disorders. This study premeditated to investigate the effect of Graviola extract (GE) on …

[HTML][HTML] In silico and in vivo analysis of the relationship between ADHD and social isolation in pups rat model: Implication of redox mechanisms, and the …

K Abu-Elfotuh, A Darwish, HMA Elsanhory, HH Alharthi… - Life Sciences, 2023 - Elsevier
Attention deficit hyperactivity disorder (ADHD) has high incidence rate among children
which may be due to excessive monosodium glutamate (MSG) consumption and social …

Aspartame and its metabolites cause oxidative stress and mitochondrial and lipid alterations in SH-SY5Y cells

LV Griebsch, EL Theiss, D Janitschke, VKJ Erhardt… - Nutrients, 2023 - mdpi.com
Due to a worldwide increase in obesity and metabolic disorders such as type 2 diabetes,
synthetic sweeteners such as aspartame are frequently used to substitute sugar in the diet …