Background Antibiotics are the most common medicines prescribed to children in hospitals
and the community, with a high proportion of potentially inappropriate use. Antibiotic misuse …

Neonatal sepsis accounts for significant morbidity and mortality, particularly among
premature infants in the Neonatal Intensive Care Unit. Abnormal vital sign patterns serve as …

Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in infants born
prematurely. After birth, the neonatal gut must acquire a healthy complement of commensal …

BACKGROUND: Substantial morbidity and excessive care variation are seen with pediatric
pneumonia. Accurate risk-stratification tools to guide clinical decision-making are needed …

Antibiotic stewardship programmes aim to optimise antimicrobial use to prevent the
emergence of resistance species and protect patients from the side effects of unnecessary …

Background and objectives C-reactive protein (CRP) has been proposed to guide the use of
antibiotics. However, study results are controversial regarding the benefits of such a …

Artificial intelligence may have a role in the early detection of sepsis in neonates. Machine
learning can identify patterns that predict high or increasing risk for clinical deterioration from …

Background Bloodstream infection (BSI) among neonatal intensive care unit (NICU) infants
is a frequent problem associated with poor outcomes. Monitoring for abnormal heart rate …

Objective Characterize C-reactive protein (CRP) within 72 postnatal hours in early-onset
sepsis (EOS). Study design Secondary analysis of a prospective surveillance study of …

Early-onset sepsis (EOS) is a significant cause of neonatal morbidity and mortality. 1 EOS
pathogenesis typically involves ascending infection of the fetal compartment by maternal …