The efficacious detection of pathogens and prompt induction of innate immune signaling
serve as a crucial component of immune defense against infectious pathogens. Over the …

Type I interferons (IFN-Is) are important cytokines playing critical roles in various infections,
autoimmune diseases, and cancer. Studies have also shown that IFN-Is exhibit …

Malaria infection triggers vigorous host immune responses; however, the parasite ligands,
host receptors, and the signaling pathways responsible for these reactions remain unknown …

Malaria reflects not only a state of immune activation, but also a state of general immune
defect or immunosuppression, of complex etiology that can last longer than the actual …

Malaria remains a serious threat to global health. Sustained malaria control and, eventually,
eradication will only be achieved with a broadly effective malaria vaccine. Yet a fundamental …

Two seminal observations suggest that the African genome contains genes selected by
malaria that protect against systemic lupus erythematosus (SLE) in individuals chronically …

Malaria elimination urgently needs novel antimalarial therapies that transcend resistance,
toxicity, and high costs. Our multicentric international collaborative team focuses on …

The Plasmodium parasites that cause malaria undergo asymptomatic development in the
parenchymal cells of the liver, the hepatocytes, prior to infecting erythrocytes and causing …

Recent initiatives to improve translation of findings from animal models to human disease
have focussed on reproducibility but quantifying the relevance of animal models remains a …

Severe malarial anemia (SMA, Hb< 6.0 g/dL) is a leading cause of childhood morbidity and
mortality in holoendemic Plasmodium falciparum transmission zones. This study explored …