Self-healing injectable hydrogels for tissue regeneration

P Bertsch, M Diba, DJ Mooney… - Chemical …, 2022 - ACS Publications
Biomaterials with the ability to self-heal and recover their structural integrity offer many
advantages for applications in biomedicine. The past decade has witnessed the rapid …

Recent advances of smart materials for ocular drug delivery

X Wang, F Luan, H Yue, C Song, S Wang… - Advanced drug delivery …, 2023 - Elsevier
Owing to the variety and complexity of ocular diseases and the natural ocular barriers, drug
therapy for ocular diseases has significant limitations, such as poor drug targeting to the site …

Hydrogels in ophthalmic applications

S Kirchhof, AM Goepferich, FP Brandl - European Journal of Pharmaceutics …, 2015 - Elsevier
More and more people worldwide are affected by severe eye diseases eventually leading to
visual impairment or blindness. In most cases, the treatment involves the application of …

Fast-forming hydrogel with ultralow polymeric content as an artificial vitreous body

K Hayashi, F Okamoto, S Hoshi, T Katashima… - Nature Biomedical …, 2017 - nature.com
Degradation-induced swelling in implanted hydrogels can cause severe adverse reactions
in surrounding tissues. Here, we report a new class of hydrogel with extremely low swelling …

Designing injectable, covalently cross‐linked hydrogels for biomedical applications

M Patenaude, NMB Smeets… - Macromolecular rapid …, 2014 - Wiley Online Library
Hydrogels that can form spontaneously via covalent bond formation upon injection in vivo
have recently attracted significant attention for their potential to address a variety of …

Polymeric hydrogels as a vitreous replacement strategy in the eye

Q Lin, JYC Lim, K Xue, X Su, XJ Loh - Biomaterials, 2021 - Elsevier
Vitreous endo-tamponades are commonly used in the treatment of retinal detachments and
tears. They function by providing a tamponading force to support the retina after retina …

Injectable hydrogels for ophthalmic applications

K Wang, Z Han - Journal of Controlled Release, 2017 - Elsevier
The demand for effective eye therapies is driving the development of injectable hydrogels as
new medical devices for controlled delivery and filling purposes. This article introduces the …

Vitreous substitutes: the present and the future

S Donati, SM Caprani, G Airaghi… - BioMed research …, 2014 - Wiley Online Library
Vitreoretinal surgery has advanced in numerous directions during recent years. The removal
of the vitreous body is one of the main characteristics of this surgical procedure. Several …

A new highly transparent injectable PHA-based thermogelling vitreous substitute

K Xue, Z Liu, L Jiang, D Kai, Z Li, X Su, XJ Loh - Biomaterials science, 2020 - pubs.rsc.org
Transparency is an important criterion for the application of biomaterials to the eye and
essential for use as a vitreous substitute. However, there is a lack of understanding on the …

Functionalised type-I collagen as a hydrogel building block for bio-orthogonal tissue engineering applications

R Ravichandran, MM Islam, EI Alarcon… - Journal of Materials …, 2016 - pubs.rsc.org
In this study, we derivatized type I collagen without altering its triple helical conformation to
allow for facile hydrogel formation via the Michael addition of thiols to methacrylates without …