The clinical and theranostic values of activated leukocyte cell adhesion molecule (ALCAM)/CD166 in human solid cancers
Y Yang, AJ Sanders, QP Dou, DG Jiang, AX Li… - Cancers, 2021 - mdpi.com
Simple Summary ALCAM (activated leukocyte cell adhesion molecule) is an important
regulator in human cancers, particularly solid tumours. Its expression in cancer tissues has …
regulator in human cancers, particularly solid tumours. Its expression in cancer tissues has …
Targeting ADAM17 sheddase activity in cancer
A disintegrin and metalloprotease (ADAM) 17 is a sheddase, capable of releasing the
ectodomains of membrane proteins such as growth factors (eg Epidermal Growth Factor …
ectodomains of membrane proteins such as growth factors (eg Epidermal Growth Factor …
Vascular ADAM17 as a novel therapeutic target in mediating cardiovascular hypertrophy and perivascular fibrosis induced by angiotensin II
T Takayanagi, SJ Forrester, T Kawai, T Obama… - …, 2016 - Am Heart Assoc
Angiotensin II (AngII) has been strongly implicated in hypertension and its complications.
Evidence suggests the mechanisms by which AngII elevates blood pressure and enhances …
Evidence suggests the mechanisms by which AngII elevates blood pressure and enhances …
N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity
Matrix metalloproteinases (MMPs) have been shown to be involved in tumor-induced
angiogenesis. In particular, MMP-2, MMP-9, and MMP-14 have been reported to be crucial …
angiogenesis. In particular, MMP-2, MMP-9, and MMP-14 have been reported to be crucial …
Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell …
C Camodeca, E Nuti, L Tepshi, S Boero… - European Journal of …, 2016 - Elsevier
Hodgkin's lymphoma (HL) is the most common malignant lymphoma in young adults in the
western world. This disease is characterized by an overexpression of ADAM-10 with …
western world. This disease is characterized by an overexpression of ADAM-10 with …
ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing
Hodgkin lymphoma (HL) resistant to conventional therapies is increasing, making of interest
the search for new schemes of treatment. Members of the “A Disintegrin And …
the search for new schemes of treatment. Members of the “A Disintegrin And …
Recent developments and strategies for the discovery of TACE inhibitors
PR Murumkar, RB Ghuge, M Chauhan… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction TNF-α plays a central role in certain autoimmune diseases as well as in
inflammation. The current strategy for excluding TNF-α from circulation is to selectively …
inflammation. The current strategy for excluding TNF-α from circulation is to selectively …
Hepatitis C virus-induced NK cell activation causes metzincin-mediated CD16 cleavage and impaired antibody-dependent cytotoxicity
Background & Aims The Fc receptor family for immunoglobulin (Ig) G type III (FcγRIII, CD16)
is an activating receptor on natural killer (NK) cells and an essential mediator of antibody …
is an activating receptor on natural killer (NK) cells and an essential mediator of antibody …
ADAM metalloproteinases as potential drug targets
The ADAMs, together with ADAMTSs and snake venom metalloproteases (SVMPs), are
members of the Adamalysin family. Differences in structural organization, functions and …
members of the Adamalysin family. Differences in structural organization, functions and …
JG26 attenuates ADAM17 metalloproteinase-mediated ACE2 receptor processing and SARS-CoV-2 infection in vitro
Background ADAM17 is a metalloprotease implicated in the proteolysis of angiotensin-
converting enzyme 2 (ACE2), known to play a critical role in the entry and spread of SARS …
converting enzyme 2 (ACE2), known to play a critical role in the entry and spread of SARS …