The excessive production of reactive oxygen species (ROS) can lead to single nucleic acid
base damage, DNA strand breakage, inter-and intra-strand cross-linking of nucleic acids …

Nucleic acid aptamers are single-stranded DNA or RNA molecules identified to recognize
with high affinity specific targets including proteins, small molecules, ions, whole cells and …

Abstract G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the
promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s …

The importance of local DNA structures in the regulation of basic cellular processes is an
emerging field of research. Amongst local non-B DNA structures, G-quadruplexes are …

Molecular mechanical (MM) force fields are commonly employed for biomolecular
simulations. Despite their success, the nonpolarizable nature of contemporary additive force …

G-Rich DNA and RNA have a higher propensity to form G-quadruplex structures, but the
presence of G-runs alone is not sufficient to prove that such sequences can form stable G …

G-quadruplex (G4) is a DNA/RNA conformation that consists of two or more G-tetrads
resulting from four-guanine bases connected by Hoogsteen-type hydrogen bonds, which is …

Mammalian antibody switch regions (∼ 1500 bp) are composed of a series of closely
neighboring G4-capable sequences. Whereas numerous structural and genome-wide …

Since the occurrence of tumours is closely associated with the telomerase function and
oncogene expression, the structure of such enzymes and genes are being recognized as …

In order to better control nosocomial infections, and facilitate the most prudent and effective
use of antibiotics, improved strategies for the rapid detection and identification of …