Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction

AS Monzel, JA Enríquez, M Picard - Nature metabolism, 2023 - nature.com
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Sedentary behavior, exercise, and cardiovascular health

CJ Lavie, C Ozemek, S Carbone… - Circulation …, 2019 - Am Heart Assoc
Sedentary behavior and physical inactivity are among the leading modifiable risk factors
worldwide for cardiovascular disease and all-cause mortality. The promotion of physical …

Mitochondrial dynamics and mitophagy in skeletal muscle health and aging

JP Leduc-Gaudet, SNA Hussain, E Barreiro… - International journal of …, 2021 - mdpi.com
The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria,
indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ …

[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals

R Furrer, JA Hawley, C Handschin - Physiological Reviews, 2023 - journals.physiology.org
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Training-induced changes in mitochondrial content and respiratory function in human skeletal muscle

C Granata, NA Jamnick, DJ Bishop - Sports Medicine, 2018 - Springer
A sedentary lifestyle has been linked to a number of metabolic disorders that have been
associated with sub-optimal mitochondrial characteristics and an increased risk of …

High-intensity exercise and mitochondrial biogenesis: current controversies and future research directions

DJ Bishop, J Botella, AJ Genders, MJC Lee… - …, 2019 - journals.physiology.org
It is well established that different types of exercise can provide a powerful stimulus for
mitochondrial biogenesis. However, there are conflicting findings in the literature, and a …

High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content

C Granata, NJ Caruana, J Botella, NA Jamnick… - Nature …, 2021 - nature.com
Mitochondrial defects are implicated in multiple diseases and aging. Exercise training is an
accessible, inexpensive therapeutic intervention that can improve mitochondrial …

Effect of exercise training on fat loss—Energetic perspectives and the role of improved adipose tissue function and body fat distribution

KJ Kolnes, MH Petersen, T Lien-Iversen… - Frontiers in …, 2021 - frontiersin.org
In obesity, excessive abdominal fat, especially the accumulation of visceral adipose tissue
(VAT), increases the risk of metabolic disorders, such as type 2 diabetes mellitus (T2DM) …

Blood flow restriction training and the high-performance athlete: science to application

C Pignanelli, D Christiansen… - Journal of Applied …, 2021 - journals.physiology.org
The manipulation of blood flow in conjunction with skeletal muscle contraction has greatly
informed the physiological understanding of muscle fatigue, blood pressure reflexes, and …

Impact of resistance training on skeletal muscle mitochondrial biogenesis, content, and function

T Groennebaek, K Vissing - Frontiers in physiology, 2017 - frontiersin.org
Skeletal muscle metabolic and contractile properties are reliant on muscle mitochondrial
and myofibrillar protein turnover. The turnover of these specific protein pools is …