Aminoglycosides are a group of antibiotics used since the 1940s to primarily treat a broad
spectrum of bacterial infections. The primary resistance mechanism against these antibiotics …

The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

Although aminoglycosides have been used as antibacterials for decades, their use has
been hindered by their inherent toxicity and the resistance that has emerged to these …

Thermodynamic rules that link RNA sequences to secondary structure are well established,
but the link between secondary structure and three-dimensional global conformation …

Carbohydrates are an important energy source and play numerous key roles in all living
organisms. Carbohydrates chemistry involved in diagnosis and treatment of diseases has …

The key role of the bacterial ribosome makes it an important target for antibacterial agents.
Indeed, a large number of clinically useful antibiotics target this complex translational …

Nonsense mutations promote premature translational termination and represent the
underlying cause of a large number of human genetic diseases. The aminoglycoside …

In this paper, we review recent DNA-binding agents that are expected to influence the field
of DNA-targeting. We restrict ourselves to binders for which the three-dimensional structure …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

Nucleic acids participate in a large number of biological processes. However, current
approaches for small molecules targeting protein are incompatible with nucleic acids. On the …