Arginine methylation is a ubiquitous post-translational modification. Three predominant
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …

Recent efforts to identify RNA binding proteins in various organisms and cellular contexts
have yielded a large collection of proteins that are capable of RNA binding in the absence of …

Especially in higher eukaryotes, the N termini of proteins are subject to enzymatic
modifications, with the acetylation of the alpha‐amino group of nascent polypeptides being a …

Emerging evidence indicated that many long non-coding (lnc) RNAs function in multiple
biological processes and dysregulation of their expression can cause diseases. Most …

RNA binding proteins (RBPs) bind RNAs through specific RNA-binding domains, generating
multi-molecular complexes known as ribonucleoproteins (RNPs). Various post-translational …

The FET sub‐family (F US/T LS, E WS, T AF15) of RNA‐binding proteins have remarkably
similar overall structure but diverse biological and pathological roles. The molecular basis …

Liquid-Liquid Phase Separation (LLPS) forms membraneless organelles, enhancing
biochemical processes. The stickers-and-spacers model explains LLPS but is mainly …

Co-transcriptional R-loops form when nascent RNA transcripts base pairs with the template
DNA strand, displacing the non-template DNA strand. Initially considered a transcriptional …

Alternative splicing (AS) is a key step in gene expression by which multiple RNA isoforms
are produced from a single gene. This process is commonly rewired in cancer cells to drive …

My thesis explores the consequences of two post-translational modifications: 1) arginine
methylation (Rme) and 2) glutamylation. Rme occurs in three different states: mono (me1) …