Type III polyketide synthases: functional classification and phylogenomics

Y Shimizu, H Ogata, S Goto - ChemBioChem, 2017 - Wiley Online Library
Polyketide synthases (PKSs) catalyze the sequential condensation of simple acetate units to
produce a large class of natural products, including pharmacologically valuable compounds …

An overview of the medicinally important plant type III PKS derived polyketides

R Bisht, A Bhattacharyya, A Shrivastava… - Frontiers in Plant …, 2021 - frontiersin.org
Plants produce interesting secondary metabolites that are a valuable source of both
medicines for human use, along with significant advantages for the manufacturer species …

Exploiting the biosynthetic potential of type III polyketide synthases

YP Lim, MK Go, WS Yew - Molecules, 2016 - mdpi.com
Polyketides are structurally and functionally diverse secondary metabolites that are
biosynthesized by polyketide synthases (PKSs) using acyl-CoA precursors. Recent studies …

How structural subtleties lead to molecular diversity for the type III polyketide synthases

H Morita, CP Wong, I Abe - Journal of Biological Chemistry, 2019 - ASBMB
Type III polyketide synthases (PKSs) produce an incredibly diverse group of plant
specialized metabolites with medical importance despite their structural simplicity compared …

Recent advances in the catalytic synthesis of 4-quinolones

C Shen, A Wang, J Xu, Z An, KY Loh, P Zhang, X Liu - Chem, 2019 - cell.com
The 4-quinolones and their analogs are a heterogeneous group of biologically active
compounds that have evolved in modern days to provide utilities at the forefront of antibiotic …

Delineating biosynthesis of Huperzine A, A plant-derived medicine for the treatment of Alzheimer's disease

X Li, W Li, P Tian, T Tan - Biotechnology Advances, 2022 - Elsevier
Huperzine A (HupA) is a plant-derived lycopodium alkaloid used for the treatment of
Alzheimer's disease due to its inhibition against acetylcholinesterase. Currently, industrial …

Tropane and granatane alkaloid biosynthesis: a systematic analysis

N Kim, O Estrada, B Chavez, C Stewart Jr, JC D'Auria - Molecules, 2016 - mdpi.com
The tropane and granatane alkaloids belong to the larger pyrroline and piperidine classes of
plant alkaloids, respectively. Their core structures share common moieties and their …

Modular metabolic engineering for production of phloretic acid, phloretin and phlorizin in Escherichia coli

X Liu, J Liu, D Lei, GR Zhao - Chemical Engineering Science, 2022 - Elsevier
Phloretic acid, phloretin and phlorizin (phloretin 2′-O-glucoside), plant-derived natural
products, are well known for human health benefits and medical application. Here, we …

A Novel Class of Plant Type III Polyketide Synthase Involved in Orsellinic Acid Biosynthesis from Rhododendron dauricum

F Taura, M Iijima, E Yamanaka, H Takahashi… - Frontiers in plant …, 2016 - frontiersin.org
Rhododendron dauricum L. produces daurichromenic acid, the anti-HIV meroterpenoid
consisting of sesquiterpene and orsellinic acid (OSA) moieties. To characterize the enzyme …

Transcriptomic insight into terpenoid and carbazole alkaloid biosynthesis, and functional characterization of two terpene synthases in curry tree (Murraya koenigii)

S Meena, S Rajeev Kumar, V Dwivedi… - Scientific Reports, 2017 - nature.com
Curry tree (Murraya koenigii L.) is a rich source of aromatic terpenes and pharmacologically
important carbazole alkaloids. Here, M. koenigii leaf transcriptome was generated to gain …