[HTML][HTML] Functions of thrombospondin-1 in the tumor microenvironment
The identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted
interest in its role in cancer biology and potential as a therapeutic target. Decreased …
interest in its role in cancer biology and potential as a therapeutic target. Decreased …
[HTML][HTML] Regulation of survival networks in senescent cells: from mechanisms to interventions
Cellular senescence is a state of stable cell cycle arrest arising in response to DNA and
mitochondrial damages. Senescent cells undergo morphological, structural and functional …
mitochondrial damages. Senescent cells undergo morphological, structural and functional …
[HTML][HTML] Thrombospondin-1 CD47 signalling: from mechanisms to medicine
Recent advances provide evidence that the cellular signalling pathway comprising the
ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range …
ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range …
[HTML][HTML] Targeting senescent cells to attenuate cardiovascular disease progression
Cardiovascular disease (CVD) is the most common disease to increase as life expectancy
increases. Most high-profile pharmacological treatments for age-related CVD have led to …
increases. Most high-profile pharmacological treatments for age-related CVD have led to …
Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway
Z Chen, J Yu, M Fu, R Dong, Y Yang, J Luo… - Biochemical …, 2020 - Elsevier
Abstract Dipeptidyl peptidase-4 (DPP4) is elevated in numerous cardiovascular pathological
processes and DPP4 inhibition is associated with reduced inflammation and oxidative …
processes and DPP4 inhibition is associated with reduced inflammation and oxidative …
Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence
In an aging population, intense interest has shifted toward prolonging health span. Mounting
evidence suggests that cellular reactive species are propagators of cell damage …
evidence suggests that cellular reactive species are propagators of cell damage …
[HTML][HTML] Senescence-associated secretory phenotype of cardiovascular system cells and inflammaging: perspectives of peptide regulation
V Khavinson, N Linkova, A Dyatlova, R Kantemirova… - Cells, 2022 - mdpi.com
A senescence-associated secretory phenotype (SASP) and a mild inflammatory response
characteristic of senescent cells (inflammaging) form the conditions for the development of …
characteristic of senescent cells (inflammaging) form the conditions for the development of …
Molecular mechanisms of endothelial dysfunction in coronary microcirculation dysfunction
Z Zhang, X Li, J He, S Wang, J Wang, J Liu… - Journal of Thrombosis …, 2023 - Springer
Coronary microvascular endothelial cells (CMECs) react to changes in coronary blood flow
and myocardial metabolites and regulate coronary blood flow by balancing vasoconstrictors …
and myocardial metabolites and regulate coronary blood flow by balancing vasoconstrictors …
CD47 activation by thrombospondin-1 in lymphatic endothelial cells suppresses lymphangiogenesis and promotes atherosclerosis
B Singla, RV Aithbathula, N Pervaiz… - … and Vascular Biology, 2023 - Am Heart Assoc
Background: TSP1 (thrombospondin-1)—a well-known angiogenesis inhibitor—mediates
differential effects via interacting with cell surface receptors including CD36 (cluster of …
differential effects via interacting with cell surface receptors including CD36 (cluster of …
[HTML][HTML] Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune …
A Głuchowska, D Cysewski, M Baj-Krzyworzeka… - Geroscience, 2022 - Springer
Atherosclerosis, a common age-related disease, is characterized by intense immunological
activity. Atherosclerotic plaque is composed of endothelial cells, vascular smooth muscle …
activity. Atherosclerotic plaque is composed of endothelial cells, vascular smooth muscle …