Epidemiological evidence indicates that regular physical activity and/or frequent structured
exercise reduces the incidence of many chronic diseases in older age, including …

Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

The common view is that T lymphocytes activate telomerase to delay senescence. Here we
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …

Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …

As global life expectancy continues to rise, we are challenged with maintaining health into
old age. One strategy is to target the chronic low-level inflammation associated with aging …

Naive T cells have long been regarded as a developmentally synchronized and fairly
homogeneous and quiescent cell population, the size of which depends on age, thymic …

All hematopoietic and immune cells are continuously generated by hematopoietic stem cells
(HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of …

Cancer cells undergo unlimited progression and survival owing to activation of oncogenes.
However, support of the tumor microenvironment is essential to the formation of clinically …

Abstract γδ T cells are considered to be innate-like lymphocytes that respond rapidly to
stress without clonal selection and differentiation. Here we use next-generation sequencing …

It is now becoming apparent that the immune system undergoes age‐associated alterations,
which accumulate to produce a progressive deterioration in the ability to respond to …