Over the past 15 years or so, numerous studies have sought to characterise how nuclear
calcium (Ca2+) signals are generated and reversed, and to understand how events that …

The roles of phosphoinositide-specific phospholipase C (PLC) have been extensively
investigated in diverse cell lines and pathological conditions. Among the PLC isozmes …

Altered abundance of phosphatidyl inositides (PI s) is a feature of cancer. Various PI s mark
the identity of diverse membranes in normal and malignant cells. Phosphatidylinositol 4, 5 …

Previous studies have demonstrated that the persistent exposure of human bronchial
epithelial cells to nicotine (Nic) through nicotinic acetylcholine receptors increases cyclin D1 …

Protein kinases C (PKCs) are a family of serine/threonine kinases which act as key
regulators in cell cycle progression and differentiation. Studies of the involvement of PKCs in …

Abstract Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation
of the genetic program responsible for muscle differentiation and osteogenesis. During …

Phosphatidylinositol (PI) metabolism represents the core of a network of signaling pathways
which modulate many cellular functions including cell proliferation, cell differentiation …

Phosphoinositide-specific phospholipases C (PI-PLCs) are involved in signaling pathways
related to critical cellular functions, such as cell cycle regulation, cell differentiation, and …

Because of their common signaling molecules, the main T cell receptor (TCR) signaling
cascades in CD4+ and CD8+ T cells are considered qualitatively identical. Herein, we show …

Calcium signalling is important for differentiation-dependent gene expression, but is also
involved in other cellular functions. Therefore, mechanisms must exist to distinguish calcium …