Pituitary adenomas are one of the most frequent intracranial tumors and occur with a
prevalence of approximately 1: 1000 in the developed world. Pituitary adenomas have a …

The classification of adenohypophysial neoplasms as “pituitary neuroendocrine
tumors”(PitNETs) was proposed in 2017 to reflect their characteristics as epithelial …

Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor
interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete …

Stratakis CA, Tichomirowa MA, Boikos S, Azevedo MF, Lodish M, Martari M, Verma S, Daly
AF, Raygada M, Keil MF, Papademetriou J, Drori‐Herishanu L, Horvath A, Tsang KM …

Context: Germline mutations of the AIP (aryl-hydrocarbon receptor interacting protein) gene
are associated with a predisposition to pituitary adenomas. Such mutations are found in …

Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable
genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon …

Context Germline mutations in the aryl hydrocarbon receptor interacting protein gene (AIP)
have been identified in young patients (age≤ 30 years old) with sporadic pituitary …

The genetic landscape of pituitary adenomas (PAs) is diverse and many of the identified
cases remain of unclear pathogenetic mechanism. Germline genetic defects account for a …

Gigantism results when a growth hormone–secreting pituitary adenoma is present before
epiphyseal fusion. In 1909, when Harvey Cushing examined the skeleton of an Irish patient …

Background Aryl hydrocarbon receptor interacting protein (AIP) mutations (AIPmut) cause
aggressive pituitary adenomas in young patients, usually in the setting of familial isolated …