The adaptation of adenoviruses as gene delivery tools has resulted in the development of
high-capacity adenoviral vectors (HC-AdVs), also known, helper-dependent or “gutless” …

Last-generation adenovirus vectors, also called helper-dependent or gutless adenovirus,
are very attractive for gene therapy because the associated in vivo immune response is …

We have developed a simple method for converting the lipid envelope of an inactivated virus
to a gene transfer vector. Hemagglutinating virus of Japan (HVJ; Sendai virus) envelope …

Glioblastoma (GB) is the most common subtype of primary brain tumor in adults. These
tumors are highly invasive, very aggressive, and often infiltrate critical neurological areas …

Glioblastoma is an aggressive brain tumor with a dismal prognosis. Gene therapy may offer
a new option for the treatment of these patients. Several gene therapy approaches have …

Helper-dependent adenovirus (HD-Ad) vectors with all adenoviral genes deleted mediate
very long-term expression of therapeutic transgenes in a variety of animal models of …

Transgene expression from helper-dependent adenoviral (HD-Ad) vectors is effective and
long lasting, but not permanent. Their use is also limited by the host response against capsid …

Human adenoviruses have been adopted as attractive vectors for in vivo gene therapy since
they have a well-characterized genomic organization, can be grown to high titres and …

Dystrophin gene transfer using helper-dependent adenoviruses (HDAd), which are deleted
of all viral genes, is a promising option to treat muscles in Duchenne muscular dystrophy …

In recent years, the development of powerful viral gene transfer techniques has greatly
facilitated the study of gene function. This review summarises some of the viral delivery …