Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …

In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

Heat-shock transcription factor 1 (HSF1) orchestrates the fast and vast cellular response to
heat shock through increased expression of heat-shock proteins. However, how HSF1 …

Biomolecular condensates that form via phase separation are increasingly regarded as
coordinators of cellular reactions that regulate a wide variety of biological phenomena …

At the turn of the twenty-first century, fundamental changes took place in the understanding
of the structure and function of proteins and then in the appreciation of the intracellular …

The fields of application of functional proteomics are not limited to the study of protein–
protein interactions; they also extend to those involving protein complexes that bind DNA or …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Paraspeckles are constructed by NEAT1_2 architectural long noncoding RNAs. Their
characteristic cylindrical shapes, with highly ordered internal organization, distinguish them …

Superenhancers drive abnormal gene expression in tumors and promote malignancy.
However, the relationship between superenhancer‐associated long noncoding RNA …