The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

Post-transcriptional regulation of gene expression plays a critical role in almost all cellular
processes. Regulation occurs mostly by RNA-binding proteins (RBPs) that recognise RNA …

Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical
for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor …

Congenital hydrocephalus (CH), featuring markedly enlarged brain ventricles, is thought to
arise from failed cerebrospinal fluid (CSF) homeostasis and is treated with lifelong surgical …

Central questions in regenerative biology include how stem cells are maintained and how
they transition from self-renewal to differentiation. Germline stem cells (GSCs) in Caeno …

TRIM-NHL proteins are key regulators of developmental transitions, for example promoting
differentiation, while inhibiting cell growth and proliferation, in stem and progenitor cells …

Motivation Identifying RNA-binding residues, especially energetically favored hot spots, can
provide valuable clues for understanding the mechanisms and functional importance of …

TRIM proteins constitute a large, diverse and ancient protein family which play a key role in
processes including cellular differentiation, autophagy, apoptosis, DNA repair, and tumour …

Background Brain tumor (BRAT) is a Drosophila member of the TRIM-NHL protein family.
This family is conserved among metazoans and its members function as post-transcriptional …

The regulation of mRNA translation, both globally and at the level of individual transcripts,
plays a central role in the development and function of germ cells across species. Genetic …