Simple Summary Rhabdomyosarcomas are soft tissue tumors more commonly found in
children than adults. The diagnosis and management of these tumors continues to change …

Simple Summary Cancer stands as the leading cause of death among children and
adolescents in the United States. Some of these pediatric cancers are highly aggressive and …

The tumor-specific chromosomal translocation product, PAX3:: FOXO1, is an aberrant fusion
protein that plays a key role for oncogenesis in the alveolar subtype of rhabdomyosarcoma …

Background Racial and ethnic disparities have been demonstrated in pediatric and adult
cancers. However, there is no consensus on whether such disparities exist in the …

Clinical trials conducted by the Intergroup Rhabdomyosarcoma (RMS) Study Group and the
Children's Oncology Group have been pivotal to establishing current standards for diagnosis …

PURPOSE Molecular markers increasingly influence risk-stratified treatment selection for
pediatric rhabdomyosarcoma (RMS). This study aims to integrate molecular and clinical data …

Abstract Background Perianal rhabdomyosarcoma ((P) RMS) are rare and have a poor
prognosis. Data in young children are limited and local therapy is not well defined …

Introduction Tumors of the soft tissue and bone in the upper and lower extremities are more
common in pediatric populations than the general adult population and often require …

Myogenesis, the progression of proliferating skeletal myoblasts to terminally differentiated
myotubes, regulates thousands of target genes. Uninterrupted linear arrays of such genes …

Alveolar rhabdomyosarcoma (ARMS) patients harboring PAX3-FOXO1 and PAX7-FOXO1
fusion proteins exhibit a greater incidence of tumor relapse, metastasis, and poor survival …