Bioinformatics is a rapidly evolving field charged with cataloging, disseminating, and
analyzing biological data. Bioinformatics started with genomics, but while genomics focuses …

Hypertrophic cardiomyopathy is one of the most common inherited cardiomyopathies and a
leading cause of sudden cardiac death in young adults. Despite profound insights into the …

Abstract Apolipoprotein E4 (ApoE 4) plays an important role responding to monomeric C-
reactive protein (mCRP) via binding to CD31 leading to cerebrovascular damage and …

Although the prevalence of heart failure with preserved ejection fraction (HFpEF) is
increasing, evidence-based therapies for HFpEF remain limited, likely due to an incomplete …

Background: Hepatocellular carcinoma (HCC) is the main cause of mortality from cancer
globally. This paper intends to classify public gene expression data of patients with Hepatitis …

Thermal nociception involves the transmission of temperature-related noxious information
from the periphery to the CNS and is a heritable trait that could predict transition to persistent …

Metabolism is recognized as an important driver of cancer progression and other complex
diseases, but global metabolite profiling remains a challenge. Protein expression profiling is …

Mass spectrometry (MS) is an important tool for biological studies because it is capable of
interrogating a diversity of biomolecules (proteins, drugs, metabolites) not captured via …

Uncompetitive inhibition is an effective strategy for suppressing dysregulated enzymes and
their substrates, but discovery of suitable ligands depends on often-unavailable structural …

High-sensitivity nanoflow liquid chromatography (nLC) is seldom employed in untargeted
metabolomics because current sample preparation techniques are inefficient at preventing …