ESSM position statement on surgical treatment of Peyronie's disease

D Osmonov, A Ragheb, S Ward, G Blecher… - Sexual …, 2022 - academic.oup.com
Abstract Introduction Patients with Peyronie's disease may experience significat distress.
The choice of treatment depends on a variety of factors, including the stage of the disease …

Role of oxidative stress in Peyronie's disease: biochemical evidence and experiences of treatment with antioxidants

G Paulis, G De Giorgio, L Paulis - International Journal of Molecular …, 2022 - mdpi.com
Background: Peyronie's disease (PD) is a chronic inflammatory condition affecting adult
males, involving the tunica albuginea of the corpora cavernosa of the penis. PD is frequently …

Daily low-dose tadalafil may reduce the penile curvature progression rate in patients with acute Peyronie's disease: a retrospective comparative analysis

L Spirito, C Manfredi, R La Rocca… - International Journal of …, 2024 - nature.com
The aim of this study was to evaluate the clinical outcomes of patients in acute phase of
Peyronie's disease (PD) treated with daily low-dose of Tadalafil. An observational …

The mechanisms and potential of stem cell therapy for penile fibrosis

U Milenkovic, M Albersen, F Castiglione - Nature Reviews Urology, 2019 - nature.com
Fibrosis is often caused by chronic tissue injury leading to a persisting inflammatory
response with excessive accumulation of extracellular connective tissue proteins. Peyronie's …

The natural history of Peyronie's disease

F Di Maida, G Cito, L Lambertini… - The World Journal …, 2020 - pmc.ncbi.nlm.nih.gov
Peyronie's disease (PD), a fibrotic disorder of the tunica albuginea fully described in 1793 by
French physician Francois de la Peyronie, is characterized by pain, plaque formation, penile …

Intratunical injection of human urine‐derived stem cells derived exosomes prevents fibrosis and improves erectile function in a rat model of Peyronie's disease

Q Yang, W Chen, D Han, C Zhang, Y Xie, X Sun… - Andrologia, 2020 - Wiley Online Library
We aimed to evaluate the effects of intratunical injection of exosomes derived from human
urine‐derived stem cells (USC‐exo) on plaque formation and erectile function in a …

A prospective multicentric international study on the surgical outcomes and patients' satisfaction rates of the 'sliding'technique for end‐stage Peyronie's disease with …

L Rolle, M Falcone, C Ceruti, M Timpano… - BJU …, 2016 - Wiley Online Library
Objectives To report the results from a prospective multicentric study of patients with
Peyronie's disease (PD) treated with the 'sliding'technique (ST). Patients and Methods From …

Molecular mechanisms and current pharmacotherapy of Peyronie's disease: a review

F Zhang, F Qin, J Yuan - Frontiers in Pharmacology, 2021 - frontiersin.org
Peyronie's disease (PD) is a localized fibrotic lesion of the penis that has adverse effects on
men's health. In this review, we summarized the molecular mechanisms and …

Effects of stem cell treatment in human patients with Peyronie disease

JA Levy, M Marchand, L Iorio, G Zribi… - Journal of Osteopathic …, 2015 - degruyter.com
Context: Peyronie disease (PD) is a connective tissue disorder involving the formation of
fibrous plaques in the tunica albuginea. Abnormal plaques and scar tissue create a chronic …

Stem cell treatment of erectile dysfunction

A Alwaal, UB Zaid, CS Lin, TF Lue - Advanced drug delivery reviews, 2015 - Elsevier
Erectile Dysfunction (ED) is a common disease that typically affects older men. While oral
type-5 phosphodieserase inhibitors (PDE5Is) represent a successful first-line therapy, many …