Epileptic encephalopathies of infancy and childhood comprise a large, heterogeneous
group of severe epilepsies characterised by several seizure types, frequent epileptiform …

The challenges to individuals with epilepsy extend far beyond the seizures. Co‐morbidities
in epilepsy are very common and are often more problematic to individuals than the seizures …

Cognitive and behavioural comorbidities are often seen in children with epilepsy, and are
more common and severe in refractory epilepsy. These comorbidities are associated with …

Voltage-gated sodium channels initiate action potentials in nerve, skeletal muscle, and other
electrically excitable cells. Mutations in them cause a wide range of diseases. These …

Background Calcium ions are involved in several human cellular processes including
corticogenesis, transcription, and synaptogenesis. Nevertheless, the relationship between …

Dravet syndrome is one of the most severe epilepsy syndromes of early childhood, and it
comes with very high morbidity and mortality. The typical presentation is characterized by …

Dravet syndrome is a devastating genetic brain disorder caused by heterozygous loss-of-
function mutation in the voltage-gated sodium channel gene SCN1A. There are currently no …

Summary Pathogenic SCN 1A/NaV1. 1 mutations cause well‐defined epilepsies, including
genetic epilepsy with febrile seizures plus (GEFS+) and the severe epileptic encephalopathy …

De novo mutations of the voltage-gated sodium channel gene SCN8A have recently been
recognized as a cause of epileptic encephalopathy, which is characterized by refractory …

Objective Reducing levels of the microtubule‐associated protein tau has shown promise as
a potential treatment strategy for diseases with secondary epileptic features such as …