Advances in development and application of influenza vaccines

J Chen, J Wang, J Zhang, H Ly - Frontiers in immunology, 2021 - frontiersin.org
Influenza A virus is one of the most important zoonotic pathogens that can cause severe
symptoms and has the potential to cause high number of deaths and great economic loss …

Intranasal vaccine: Factors to consider in research and development

H Xu, L Cai, S Hufnagel, Z Cui - International journal of pharmaceutics, 2021 - Elsevier
Most existing vaccines for human use are administered by needle-based injection.
Administering vaccines needle-free intranasally has numerous advantages over by needle …

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization

D Lapuente, J Fuchs, J Willar, A Vieira Antão… - Nature …, 2021 - nature.com
Several effective SARS-CoV-2 vaccines are currently in use, but effective boosters are
needed to maintain or increase immunity due to waning responses and the emergence of …

Nasal delivery as a strategy for the prevention and treatment of COVID-19

F Sonvico, G Colombo, E Quarta… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The upper respiratory tract is a major route of infection for COVID-19 and other
respiratory diseases. Thus, it appears logical to exploit the nose as administration site to …

Recent advances in respiratory immunization: A focus on COVID-19 vaccines

X He, X Chen, H Wang, G Du, X Sun - Journal of Controlled Release, 2023 - Elsevier
The development of vaccines has always been an essential task worldwide since vaccines
are regarded as powerful weapons in protecting the global population. Although the vast …

Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine

X Lin, Y Sheng, X Zhang, Z Li, Y Yang, J Wu… - Journal of Controlled …, 2022 - Elsevier
Effective antigen delivery and immune stimulation in nasal mucosa determine the success of
mucosal immunity. Here, an oil-in-ionic liquid (o/IL) nanoemulsion formulated with choline …

A comparison of etiology, pathogenesis, vaccinal and antiviral drug development between influenza and COVID-19

J Luo, Z Zhang, S Zhao, R Gao - International journal of molecular …, 2023 - mdpi.com
Influenza virus and coronavirus, two kinds of pathogens that exist widely in nature, are
common emerging pathogens that cause respiratory tract infections in humans. In December …

[HTML][HTML] Development of mucosal vaccine delivery: an overview on the mucosal vaccines and their adjuvants

R Anggraeni, ID Ana… - Clinical and Experimental …, 2022 - ncbi.nlm.nih.gov
Currently, mucosal infectious diseases are still a very high global health burden, but there
are few effective vaccines to prevent mucosal-borne diseases. The development of mucosal …

Saliva as a useful tool for evaluating upper mucosal antibody response to influenza

Y Tsunetsugu-Yokota, S Ito, Y Adachi, T Onodera… - PLoS …, 2022 - journals.plos.org
Mucosal immunity plays a crucial role in controlling upper respiratory infections, including
influenza. We established a quantitative ELISA to measure the amount of influenza virus …

Chrysanthemum sporopollenin: A novel vaccine delivery system for nasal mucosal immunity

J Liu, XD Yan, XQ Li, YH Du, LL Zhu, TT Ye… - Frontiers in …, 2023 - frontiersin.org
Objective Mucosal immunization was an effective defender against pathogens. Nasal
vaccines could activate both systemic and mucosal immunity to trigger protective immune …