Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …

Sphingolipids are structurally and functionally diverse molecules with significant physiologic
functions and are found associated with cellular membranes and plasma lipoproteins. The …

Macrophage apoptosis and the ability of macrophages to clean up dead cells, a process
called efferocytosis, are crucial determinants of atherosclerosis lesion progression and …

Type II diabetes mellitus and its related complications are growing public health problems.
Many natural products present in our diet, including polyphenols, can be used in treating …

Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are
amongst the most prescribed medications worldwide. Most statins work as a competitive …

Glucocorticoids (GCs) are commonly used at high doses and for prolonged periods (weeks
to months) in the treatment of a variety of diseases. Among the many side effects are …

The specific interest concerning HDL cholesterol (HDL-C) is related to its ability to uptake
and return surplus cholesterol from peripheral tissues back to the liver and, therefore, to its …

Over the past two decades, it was discovered that introducing synthetic small interfering
RNAs (siRNAs) into the cytoplasm facilitates effective gene-targeted silencing. This …

Extracellular vesicles (EVs) and lipoproteins are abundant and co-exist in blood. Both have
been proven to be valuable as diagnostic biomarkers and for therapeutics. However, EVs …

Cardiovascular disease (CVD) is still the leading cause of death globally, and
atherosclerosis is the main pathological basis of CVDs. Low-density lipoprotein cholesterol …