The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-
specific cell behaviour. The molecules that are associated with the ECM of each tissue …

Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and
metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with …

The bone marrow constitutes the primary site for life-long blood production and skeletal
regeneration. However, its cellular and spatial organization remains controversial. Here, we …

Cells within tissues are continuously exposed to physical forces including hydrostatic
pressure, shear stress, and compression and tension forces. Cells dynamically adapt to …

The transition of cell–matrix adhesions from the initial punctate focal complexes into the
mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

The pathological events leading to the destruction of the periodontium during inflammatory
periodontal diseases are likely to represent complex interactions involving an imbalance in …

Biomedical researchers have become increasingly aware of the limitations of conventional 2-
dimensional tissue cell culture systems, including coated Petri dishes, multi-well plates and …

The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in
regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is …

To design a mesoscopically ordered structure of the matrices and scaffolds composed of
nano-and microscale fiber meshes for artificial and tissue-engineering devices, two new …