[HTML][HTML] A review of the recent development in the synthesis and biological evaluations of pyrazole derivatives

O Ebenezer, M Shapi, JA Tuszynski - Biomedicines, 2022 - mdpi.com
Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an
important class of compounds for drug development; thus, they have attracted much …

Current development of pyrazole–azole hybrids with anticancer potential

S Zhang, Y Ye, Q Zhang, Y Luo, ZC Wang… - Future Medicinal …, 2023 - Taylor & Francis
Chemotherapy is a critical treatment modality for cancer patients, but multidrug resistance
remains one of the major challenges in cancer therapy, creating an urgent need for the …

Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination …

SA Ibrahim, EA Fayed, HF Rizk, SE Desouky… - Bioorganic …, 2021 - Elsevier
Microbial resistance is a big concern worldwide, making the development of new
antimicrobial drugs difficult. The thiazole and pyrazole rings are important heterocyclic …

Synthesis, and docking studies of novel heterocycles incorporating the indazolylthiazole moiety as antimicrobial and anticancer agents

NTA Dawoud, EM El-Fakharany, AE Abdallah… - Scientific Reports, 2022 - nature.com
The current study was directed toward developing a new series of fused heterocycles
incorporating indazolylthiazole moiety. The newly synthesized compounds were …

Design, Synthesis, Cytotoxicity Profiling, Molecular Docking and ADMET Studies of Novel Functionalized Coumarin-pyrazole-thiazole Hybrids: Cyclization of …

TE Ali, AK Alsolimani, MA Assiri, AA Shati… - Current Organic …, 2025 - benthamdirect.com
A simple synthetic method was performed to design a novel series of polycyclic systems
consisting of a coumarin-pyrazole-thiazole skeleton linked with a completed thiazole ring via …

Recent advances in the multicomponent synthesis of heterocycles using thiosemicarbazide

R Javahershenas, J Han, M Kazemi… - ChemistrySelect, 2024 - Wiley Online Library
This review provides an overview of the recent advances in the synthesis of diverse
heterocyclic compounds using thiosemicarbazide as a key building block via …

Polyethylene glycol mediated, novel, one-pot three-component synthesis of benzimidazolyl-thiazoles as potent α-glucosidase inhibitors: Design, synthesis, molecular …

R Chedupaka, K Gangarapu, S Mamidala… - Journal of Molecular …, 2023 - Elsevier
Polyethylene glycol promoted, novel, one-pot, three-component synthesis of benzimidazole
based thaizole derivatives (4a-s) has been synthesized via a multi-component approach by …

Novel Coumarin‐Pyrazole‐Thiazoles Hybrids: Synthesis, Anticancer Activity, Molecular Docking and In Silico ADMET prediction Studies

AK Alsolimani, TE Ali, MA Assiri, AA Shati… - …, 2024 - Wiley Online Library
A novel series of coumarin‐pyrazole‐thiazoles hybrids was designed. The methodology
depended on a simple condensation reaction of 3‐(2‐oxo‐2H‐chromen‐3‐yl)‐1‐phenyl‐1H …

Synthesis and biological evaluation of some new heterocyclic compounds incorporating sulfapyridine as potential antimicrobial agents

SM El-Gendy, EM Keshk, AGM Khalil, A Fekri - Journal of Molecular …, 2025 - Elsevier
This study investigated the cyanoacylation of the sulfapyridine moiety using cyanoacetyl
pyrazole as a key synthetic intermediate for the construction of diverse bioactive scaffolds …

Application of phenacyl bromide analogs as a versatile organic intermediate for the synthesis of heterocyclic compounds via multicomponent reactions

R Javahershenas - Molecular Diversity, 2023 - Springer
Due to the increased interest in heterocyclic compounds over the past decade, many
pharmaceutical and organic chemists have explored the synthesis of various materials …