Clinical implementation of pharmacogenomics for personalized precision medicine: barriers and solutions

ME Klein, MM Parvez, JG Shin - Journal of pharmaceutical sciences, 2017 - Elsevier
Clinical implementation of pharmacogenomics (PGx) leads to personalized medicine, which
improves the efficacy, safety, and cost-effectiveness of treatments. Although PGx-based …

Integrating pharmacogenomics into electronic health records with clinical decision support

JK Hicks, HM Dunnenberger… - American journal of …, 2016 - academic.oup.com
Purpose Existing pharmacogenomic informatics models, key implementation steps, and
emerging resources to facilitate the development of pharmacogenomic clinical decision …

The pharmacogenomics research network translational pharmacogenetics program: outcomes and metrics of pharmacogenetic implementations across diverse …

JA Luzum, RE Pakyz, AR Elsey… - Clinical …, 2017 - Wiley Online Library
Numerous pharmacogenetic clinical guidelines and recommendations have been
published, but barriers have hindered the clinical implementation of pharmacogenetics. The …

Multisite Investigation of Strategies for the Implementation of CYP2C19 Genotype‐Guided Antiplatelet Therapy

PE Empey, JM Stevenson, S Tuteja… - Clinical …, 2018 - Wiley Online Library
CYP2C19 genotype‐guided antiplatelet therapy following percutaneous coronary
intervention is increasingly implemented in clinical practice. However, challenges such as …

Opportunities, resources, and techniques for implementing genomics in clinical care

TA Manolio, R Rowley, MS Williams, D Roden… - The Lancet, 2019 - thelancet.com
Advances in technologies for assessing genomic variation and an increasing understanding
of the effects of genomic variants on health and disease are driving the transition of …

Implementation of a multidisciplinary pharmacogenomics clinic in a community health system

HM Dunnenberger, M Biszewski, GC Bell… - American Journal of …, 2016 - academic.oup.com
Purpose The development and implementation of a multidisciplinary pharmacogenomics
clinic within the framework of an established community-based medical genetics program …

Knowledge, perceptions and confidence of physicians and pharmacists towards pharmacogenetics practice in Kuwait

A Albassam, S Alshammari, G Ouda, S Koshy, A Awad - PloS one, 2018 - journals.plos.org
Background Pharmacogenetics practice has been successfully implemented in many
developed countries to enhance personalized medicine and improve clinical and economic …

Implementation of clinical pharmacogenomics within a large health system: from electronic health record decision support to consultation services

JK Hicks, D Stowe, MA Willner, M Wai… - … : The Journal of …, 2016 - Wiley Online Library
The number of clinically relevant gene‐based guidelines and recommendations pertaining
to drug prescribing continues to grow. Incorporating gene–drug interaction information into …

Hypertension pharmacogenomics: in search of personalized treatment approaches

RM Cooper-DeHoff, JA Johnson - Nature Reviews Nephrology, 2016 - nature.com
Cardiovascular and renal diseases are associated with many risk factors, of which
hypertension is one of the most prevalent. Worldwide, blood pressure control is only …

Educational strategies to enable expansion of pharmacogenomics-based care

KW Weitzel, CL Aquilante, S Johnson… - American Journal of …, 2016 - academic.oup.com
Purpose The current state of pharmacogenomics education for pharmacy students and
practitioners is discussed, and resources and strategies to address persistent challenges in …