Proteins are the working horse of the cellular machinery. They are responsible for diverse
functions ranging from molecular motors to signaling. They catalyze reactions, transport …

Most methods annotating protein function utilise sequence homology to proteins of
experimentally known function. Such a homology-based annotation transfer is problematic …

Zinc is one of the metal ions essential for life, as it is required for the proper functioning of a
large number of proteins. Despite its importance, the annotation of zinc-binding proteins in …

One of the most intellectually challenging, scientifically productive, and socially applicable
endeavors of modern biological science is the current effort to understand the function of …

Two approaches to structure-based drug design, that is, the docking of known compounds
into a target protein and molecular assembly in situ, are seen to be merging technologies …

Here, we present a diverse, structurally nonredundant data set of two‐chain protein–protein
interfaces derived from the PDB. Using a sequence order‐independent structural …

Over the last decade, structural biologists have unravelled many proteins that appear
natively disordered. Common assumptions are that many of these proteins adopt structure …

CASP has now completed a decade of monitoring the state of the art in protein structure
prediction. The quality of structure models produced in the latest experiment, CASP6, has …

The UBX domain is an 80 amino acid residue module that is present typically at the carboxyl
terminus of a variety of eukaryotic proteins. In an effort to elucidate the function of UBX …

Proteins are the most essential and versatile macromolecules of life, and the knowledge of
their functions is a crucial link in the development of new drugs, better crops, and even the …