[HTML][HTML] Don't fear 'fear conditioning': Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear

TB Lonsdorf, MM Menz, M Andreatta… - Neuroscience & …, 2017 - Elsevier
The so-called 'replicability crisis' has sparked methodological discussions in many areas of
science in general, and in psychology in particular. This has led to recent endeavours to …

The role of associative fear and avoidance learning in anxiety disorders: Gaps and directions for future research

A Pittig, M Treanor, RT LeBeau, MG Craske - … & Biobehavioral Reviews, 2018 - Elsevier
Anxiety disorders are the most common mental disorders and are often chronic and
disabling. Although exposure-based treatments are effective, a substantial number of …

From Pavlov to PTSD: the extinction of conditioned fear in rodents, humans, and anxiety disorders

MB VanElzakker, MK Dahlgren, FC Davis… - Neurobiology of learning …, 2014 - Elsevier
Abstract Nearly 100 years ago, Ivan Pavlov demonstrated that dogs could learn to use a
neutral cue to predict a biologically relevant event: after repeated predictive pairings …

Stress and fear extinction

S Maren, A Holmes - Neuropsychopharmacology, 2016 - nature.com
Stress has a critical role in the development and expression of many psychiatric disorders,
and is a defining feature of posttraumatic stress disorder (PTSD). Stress also limits the …

Fear extinction and relapse: state of the art

B Vervliet, MG Craske, D Hermans - Annual review of clinical …, 2013 - annualreviews.org
Exposure-based treatments for clinical anxiety generally are very effective, but relapse is not
uncommon. Likewise, laboratory studies have shown that conditioned fears are easy to …

Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits

A Caspi, AR Hariri, A Holmes, R Uher… - American journal of …, 2010 - Am Psychiatric Assoc
Evidence of marked variability in response among people exposed to the same
environmental risk implies that individual differences in genetic susceptibility might be at …

More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans-Biological, experiential, temperamental factors, and …

TB Lonsdorf, CJ Merz - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Why do only some individuals develop pathological anxiety following adverse events? Fear
acquisition, extinction and return of fear paradigms serve as experimental learning models …

Emotion processing and the amygdala: from a'low road'to'many roads' of evaluating biological significance

L Pessoa, R Adolphs - Nature reviews neuroscience, 2010 - nature.com
A subcortical pathway through the superior colliculus and pulvinar to the amygdala is
commonly assumed to mediate the non-conscious processing of affective visual stimuli. We …

Culture–gene coevolution of individualism–collectivism and the serotonin transporter gene

JY Chiao, KD Blizinsky - Proceedings of the Royal …, 2010 - royalsocietypublishing.org
Culture–gene coevolutionary theory posits that cultural values have evolved, are adaptive
and influence the social and physical environments under which genetic selection operates …

Impaired safety signal learning may be a biomarker of PTSD

T Jovanovic, A Kazama, J Bachevalier, M Davis - Neuropharmacology, 2012 - Elsevier
A dysregulated fear response is one of the hallmark clinical presentations of patients
suffering from posttraumatic stress disorder (PTSD). These patients show over …