Modulation of brain hyperexcitability: potential new therapeutic approaches in Alzheimer's disease
People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …
The function and pathogenic mechanism of filamin A
J Zhou, X Kang, H An, Y Lv, X Liu - Gene, 2021 - Elsevier
Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the
cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …
cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …
Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development
LH Burns, Z Pei, HY Wang - Drug Development Research, 2023 - Wiley Online Library
The decades‐old cholinergic hypothesis of Alzheimer's disease (AD) led to clinical testing
and FDA approval of acetylcholinesterase inhibitor drugs. Subsequently, the α7 nicotinic …
and FDA approval of acetylcholinesterase inhibitor drugs. Subsequently, the α7 nicotinic …
Convergent and divergent mechanisms of epileptogenesis in mTORopathies
Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to
mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a …
mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a …
mTORC2 inhibition improves morphological effects of PTEN loss, but does not correct synaptic dysfunction or prevent seizures
Hyperactivation of PI3K/PTEN-mTOR signaling during neural development is associated
with focal cortical dysplasia (FCD), autism, and epilepsy. mTOR can signal through two …
with focal cortical dysplasia (FCD), autism, and epilepsy. mTOR can signal through two …
The neurodevelopmental pathogenesis of tuberous sclerosis complex (TSC)
DM Feliciano - Frontiers in Neuroanatomy, 2020 - frontiersin.org
Tuberous sclerosis complex (TSC) is a model disorder for understanding brain development
because the genes that cause TSC are known, many downstream molecular pathways have …
because the genes that cause TSC are known, many downstream molecular pathways have …
Cortical dysplasia and the mTOR pathway: How the study of human brain tissue has led to insights into epileptogenesis
Type II focal cortical dysplasia (FCD) is a neuropathological entity characterised by cortical
dyslamination with the presence of dysmorphic neurons only (FCDIIA) or the presence of …
dyslamination with the presence of dysmorphic neurons only (FCDIIA) or the presence of …
Chloride deregulation and GABA depolarization in MTOR related malformations of cortical development
N Bakouh, R Castaño-Martín, A Metais, EL Dan… - Brain, 2024 - academic.oup.com
Chloride deregulation and GABA depolarization in MTOR-related malformations of cortical
development Page 1 https://doi.org/10.1093/brain/awae262 BRAIN 2024: 00; 1–15 | 1 Chloride …
development Page 1 https://doi.org/10.1093/brain/awae262 BRAIN 2024: 00; 1–15 | 1 Chloride …
Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice
The causative link between focal cortical malformations (FCMs) and epilepsy is well
accepted, especially among patients with focal cortical dysplasia type II (FCDII) and …
accepted, especially among patients with focal cortical dysplasia type II (FCDII) and …
Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer's Disease
Simufilam is a novel oral drug candidate in Phase 3 clinical trials for Alzheimer's disease
(AD) dementia. This small molecule binds an altered form of filamin A (FLNA) that occurs in …
(AD) dementia. This small molecule binds an altered form of filamin A (FLNA) that occurs in …