Transition-metal catalysis has revolutionized chemical synthesis, with the study and
implementation of new metal complexes and reaction types ubiquitous in both academic …

The ligand, P (o-tolyl) 3, is ubiquitous in applied synthetic chemistry and catalysis,
particularly in Pd-catalyzed processes, which typically include Pd (OAc) 2 (most commonly …

Carbon–carbon (C–C) bonds are ubiquitous but are among the least reactive bonds in
organic chemistry. Recently, catalytic approaches to activate C–C bonds by transition metals …

From a careful analysis of the recent literature, it seems clear that many transition-metal-
catalyzed processes used in API synthesis are developed without resorting to any kind of …

Automated chemistry platforms have been widely explored, but many focus on fixed tasks for
chemical synthesis or analysis. However, a typical synthetic chemistry workflow utilizes both …

Aryl aldehydes are key synthetic intermediates in the manufacturing of active
pharmaceutical ingredients. They are generated on scale (> 1000 kg) through the palladium …

In the vast majority, kinetic modeling is done under isothermal conditions. The benefit of the
adiabatic mode is using temperature as an online observable. Nevertheless, in the adiabatic …

High-throughput experimentation (HTE) is an important tool in pharmaceutical process
research and development. However, most of the current HTE workflows do not monitor …

The ability and desire to collect kinetic data has greatly increased in recent years, requiring
more automated and quantitative methods for analysis. In this work, an automated program …

The rapid emergence of large language model (LLM) technology presents significant
opportunities to facilitate the development of synthetic reactions. In this work, we leveraged …