The SOX family of high-mobility group (HMG) domain proteins has recently been recognized
as a key player in the regulation of embryonic development and in the determination of the …

Maintain stemness, commit to a specific lineage, differentiate, proliferate, or die. These are
essential decisions that every cell is constantly challenged to make in multi-cellular …

Sequence preferences of DNA binding proteins are a primary mechanism by which cells
interpret the genome. Despite the central importance of these proteins in physiology …

Cell fate decisions require appropriate regulation of key genes. Sox9, a direct target of SRY,
is pivotal in mammalian sex determination. In vivo high-throughput chromatin accessibility …

Transcriptional cascades that operate over the course of lineage development are
fundamental mechanisms that control cellular differentiation. In the developing central …

SOX9 is a transcription factor that plays a key role in chondrogenesis. Aggrecan is one of the
major structural components in cartilage; however, the molecular mechanism of aggrecan …

In humans, SOX9 heterozygous mutations cause the severe skeletal dysmorphology
syndrome campomelic dysplasia. Except for clinical descriptions, little is known about the …

Waardenburg syndrome (WS) is an autosomal dominant disorder with an incidence of 1 in
40 000 that manifests with sensorineural deafness and pigmentation defects. It is classified …

The transcription factor SOX9 is essential for the development of multiple organs including
bone, testis, heart, lung, pancreas, intestine and nervous system. Mutations in the human …

Members of the POU and SOX transcription factor families exemplify the partnerships
established between various transcriptional regulators during early embryonic development …