Matrix metalloproteases (MMPs) are key regulatory molecules in the formation, remodeling,
and degradation of extracellular matrix (ECM) components in both physiological and …

In skeletal muscles, levels and activity of Matrix MetalloProteinases (MMPs) and Tissue
Inhibitors of MetalloProteinases (TIMPs) have been involved in myoblast migration, fusion …

During recent years, increased efforts have focused on elucidating the secretory function of
skeletal muscle. Through secreted molecules, skeletal muscle affects local muscle biology in …

Background Duchenne muscular dystrophy (DMD) is the most common, lethal disease of
childhood. One of 3500 new-born males suffers from this universally-lethal disease. Other …

Matrix metalloproteinases (MMPs) are a group of proteases that belong to the metazincin
family. These proteins consist of similar structures featuring a signaling peptide, a …

Matrix metalloproteinases (MMPs) are members of an enzyme family that require a zinc ion
at their active site. Active at neutral pH, they catalyze normal turnover of extracellular matrix …

Methods: Mice with total and satellite cell specific Mmp13 deletion were utilized to determine
the importance of MMP-13 for postnatal growth, regeneration after acute injury, and in …

Efficient skeletal muscle repair and regeneration require coordinated remodeling of the
extracellular matrix (ECM). Previous reports have indicated that matrix metalloproteinases …

The phosphodiesterases inhibitor pentoxifylline gained attention for Duchenne muscular
dystrophy therapy for its claimed anti-inflammatory, antioxidant, and antifibrotic action. A …

Vertebrate skeletal muscle fibers have two traits that make them unique: the fibers are
multinucleated and their nuclei are post-mitotic. The activity and mass of the muscles in the …