Current yeast metabolic engineering in isoprenoids production mainly focuses on rewiring of
cytosolic metabolic pathway. However, the precursors, cofactors and the enzymes are …

Mitochondria are responsible for a series of metabolic functions. Superoxide leakage from
the respiratory chain and the resulting cascade of reactive oxygen species-induced damage …

Increasing evidence has revealed that RNA subcellular localization is a very important
feature for deeply understanding RNA's biological functions after being transported into intra …

Here we present ComPPI, a cellular compartment-specific database of proteins and their
interactions enabling an extensive, compartmentalized protein–protein interaction network …

Abstract Changes in protein subcellular localization and abundance are central to biological
regulation in eukaryotic cells. Quantitative measures of protein dynamics in vivo are …

Living organisms change their proteome dramatically to sustain a stable internal milieu in
fluctuating environments. To study the dynamics of proteins during stress, we measured the …

Altered mitochondrial functionality can extend organism life span, but the underlying
mechanisms are obscure. Here we report that inactivating SOV1, a member of the yeast …

Identifying protein–protein interactions (PPIs) is critical for understanding the cellular
function of the proteins and the machinery of a proteome. Data of PPIs derived from high …

Protein phosphorylation catalyzed by kinases plays crucial regulatory roles in intracellular
signal transduction. With the increasing number of experimental phosphorylation sites that …

Fungal infections arise frequently in immunocompromised patients, and sterol synthesis is a
primary pathway targeted by antifungal drugs. In particular, the P450 protein Erg11/Cyp51 …