Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

The Wnt pathway is involved in several processes essential for bone development and
homeostasis. For proper functioning, the Wnt pathway is tightly regulated by numerous …

Background Epigenetic alterations contribute greatly to metastasis and dissemination in
hepatocellular carcinoma (HCC). SMARCC1, as a SWI/SNF chromatin remodeling factor …

Studies on the gene regulation of spermatogenesis are of unusual significance for
maintaining male reproduction and treating male infertility. Here, we have demonstrated, for …

The regulation of bone mineral density (BMD) is highly influenced by genetics and age.
Although genome‐wide association studies (GWAS) for BMD have uncovered many genes …

Oncohistones represent compelling evidence for a causative role of epigenetic perturbations
in cancer. Giant cell tumours of bone (GCTs) are characterised by a mutated histone H3. 3 …

Histone hypermethylation represses gene transcription, which affects cartilage homeostasis
or joint remodeling. Trimethylation of lysine 27 of histone 3 (H3K27me3) changes …

Osteoporosis is a metabolic bone disease that impairs bone mineral density,
microarchitecture, and strength. It requires continuous management, and further research …

Alternative lengthening of telomeres (ALTs) mechanism is activated in some somatic, germ
cells, and human cancer cells. However, the key regulators and mechanisms of the ALT …

Abstract Purpose of the Review Herein, we report on the proceedings of the workshop
entitled “Post-Genome analysis for musculoskeletal biology” that was held in July of 2022 in …